The reduction in the volume of the growth hormone in the blood causes some major impact on many body functions. In order to reduce or even remove the chances of such abnormalities, growth hormone stimulating peptides are provided to the body through external means.
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GHRP-6
Growth Hormone Releasing Peptide or also known as GHRP-6 is one of the many kinds of synthetic peptides that are required for one or the other body functions in people. One of such issues is chronic hypercortisolism.
When there is no healthy response of growth hormone to GHRH, it results in chronic hypercortisolism. In order to learn in detail about this condition, many subjects with the excess presence of both the exogenous and endogenous glucocorticoid were selected.
The results from the experiment clearly shed light on the fact that GHRP-6 and GHRH had different results to the effect of hypercortisolism. The GH releasing factor in the finalized test subjects also stated that the effect of hypercortisolism varied accordingly in each individual.
As the tests were continued with the growth hormone and the effects of the peptides on the hormone, the researchers always came to the same conclusion, which was already stated by their senior or fellow scientists in the world of growth hormone stimulation. In the last decade, a full stop was etched to the scientists and the research, which were offering the same results again and again.
A new or also known as a third mechanism in growth hormone stimulation was discovered and was named somatostatin modulate GH secretion. This process involved studying the action carried out by the GH secretagogues.
Ghrelin
Ghrelin is one of the types of acylated peptides that can become responsible for the release of growth hormone, in the body of humans and animals, in required quantities. This acylated peptide is also known for increasing the food intake mechanism in such individuals suffering from lack of appetite issue.
Ghrelin hormone is also known as novel hormone and this hormone is normally secreted in the stomach glands in both the humans and animals. This hormone is rich in both the paracrine and endocrine effects and is produced in the hypothalamus region of the brain, apart from the stomach glands.
For successful intake of food by the individuals, it is necessary that the acyl modification in the ghrelin molecule is carried out, when this hormone is released to the bloodstreams. Since the decade old discovery by the researchers, there are many questions that require answering regarding ghrelin and the GH modulation.
To conclude, researchers have understood that ghrelin, when released can amplify the pattern in which GH is released in the body. It can even optimize the responsiveness of the somatotroph according to the release of GH. However, nothing is a 100% sure till now.
